Other side effects do not require medical attention and may go away during treatment. Some side effects may require medical attention. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious. Some patients may experience other side effects that are not listed here. This is not a complete list of side effects. What are the most common side effects of treatment with Praxbind? How is Praxbind typically given (administered)? Praxbind is given as an infusion into a vein. This allows thrombin to resume its role in the coagulation process in blood cells. Praxbind binds with Pradaxa with higher affinity than the Pradaxa does to the thrombin. Thrombin is a key element in the coagulation process. What is the mechanism of action? Praxbind is a monoclonal antibody made to reverse Pradaxa, a compound that directly blocks thrombin. However, an antidote that works on these drugs is under development, with approval expected within the next year or so.For which conditions is this drug approved? Praxbind® is indicated for patients specifically treated with Pradaxa® (dabigatran etexilate mesylate), an anti-clotting agent, when reversal of the anti-clotting effects of the agent is needed for emergency procedures, life-threatening instances, or uncontrolled bleeding. Because idarucizumab works specifically on dabigatran, it can't be used as an antidote for similar anti-clotting medications, which include rivaroxaban (Xarelto), apixaban (Eliquis), and edoxaban (Savaysa). It's also prescribed to prevent and treat venous thromboembolism. Given by injection into a vein, the drug binds to dabigatran and neutralizes its effect, allowing the blood to clot normally.ĭabigatran was approved in 2010 to prevent strokes (most of which are caused by blood clots in the brain) in people with atrial fibrillation. But in October, the FDA approved idarucizumab (Praxbind), a drug that quickly reverses the effects of dabigatran. For people who take anti-clotting drugs such as dabigatran (Pradaxa), one serious downside has been the rare but dangerous risk of uncontrolled bleeding in the event of an accident or urgently needed surgery.
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